About TFP

Funding Research for Trifunctional Protein Deficiency (TFP)

What is Trifunctional Protein Deficiency (TFP)?

Trifunctional Protein Deficiency (TFP) is a rare, inherited metabolic disorder that affects the body’s ability to break down certain fats into energy. This condition impacts the mitochondria—our cells’ power plants—which means that vital organs like the heart, liver, and muscles may not get the energy they need to function properly. TFP can present in early infancy or childhood, sometimes with life-threatening consequences, and may cause symptoms such as low blood sugar, muscle weakness, heart problems, and difficulty feeding.

TFP is part of a group of disorders known as fatty acid oxidation disorders (FAODs). Because of its rarity, many doctors and hospitals aren’t familiar with TFP, which can lead to delayed diagnosis or mismanagement. That’s why awareness and research are so important.

Why Early Detection Matters

For many children with TFP, early detection can be the difference between life and death. Newborn screening programs in some states now include TFP, but not all do—and even when detected, treatment options are extremely limited. With proper diagnosis, families can take preventive measures like special diets, medications, and emergency plans that reduce the risk of major health crises.

Still, TFP is a life-altering diagnosis, and families often find themselves navigating a maze of specialists and uncertainty. More research is urgently needed to better understand how TFP works, how it progresses, and how to treat it more effectively.

The State of Research — and the Road Ahead

Despite its seriousness, TFP is severely underfunded and understudied. Fewer than 100 children in the United States are known to be living with this condition, which means it often gets overlooked by major research institutions and pharmaceutical companies. But each of those children, like Sawyer, deserves a future filled with hope—not fear.

Thanks to the generosity of donors, Sawyer’s Race for Research has already raised over $425,000, which has helped fund cutting-edge studies and accelerate the search for better treatments. Our dream is to one day help find a cure—but that can only happen with your continued support.

How You Can Make a Difference

When you support Sawyer’s Race for Research, you’re not just helping one child—you’re fueling hope for every family affected by TFP. Your donations go directly toward scientific research, clinical trials, and resources that empower families and doctors alike. Whether you give $5 or $500, volunteer your time, or simply share our mission on social media, you become a vital part of this movement.

We believe no child should have to fight this battle alone. With your help, we can give families the answers, support, and future they deserve. Join us—and let’s race for a cure, together.